1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 13 2 Introduction 14 2.1 Pancreatic and Bile Duct Cancer Report Coverage 14 2.2 Pancreatic Cancer - Overview 14 2.3 Bile Duct Cancer (Cholangiocarcinoma) - Overview 14 3 Therapeutics Development 15 3.1 Pancreatic Cancer 15 3.2 Bile Duct Cancer (Cholangiocarcinoma) 67 4 Therapeutics Assessment 81 4.1 Pancreatic Cancer 81 4.2 Bile Duct Cancer (Cholangiocarcinoma) 113 5 Companies Involved in Therapeutics Development 125 5.1 Pancreatic Cancer 125 5.2 Bile Duct Cancer (Cholangiocarcinoma) 287 6 Dormant Projects 328 6.1 Pancreatic Cancer 328 6.2 Bile Duct Cancer (Cholangiocarcinoma) 344 7 Discontinued Products 347 7.1 Pancreatic Cancer 347 7.2 Bile Duct Cancer (Cholangiocarcinoma) 351 8 Product Development Milestones 352 8.1 Pancreatic Cancer 352 8.2 Bile Duct Cancer (Cholangiocarcinoma) 369 9 Appendix 384 9.1 Methodology 384 9.2 Coverage 384 9.3 Secondary Research 384 9.4 Primary Research 384 9.5 Expert Panel Validation 384 9.6 Contact Us 385 9.7 Disclaimer 385

1.1 List of Tables Table 1: Number of Products under Development for Pancreatic Cancer 15 Table 2: Number of Products under Development by Companies, Pancreatic Cancer 17 Table 3: Number of Products under Development by Universities/Institutes, Pancreatic Cancer 30 Table 4: Products under Development by Companies, Pancreatic Cancer 32 Table 5: Products under Development by Universities/Institutes, Pancreatic Cancer 62 Table 6: Number of Products under Development for Bile Duct Cancer (Cholangiocarcinoma) 67 Table 7: Number of Products under Development by Companies, Bile Duct Cancer (Cholangiocarcinoma) 69 Table 8: Number of Products under Development by Universities/Institutes, Bile Duct Cancer (Cholangiocarcinoma) 72 Table 9: Products under Development by Companies, Bile Duct Cancer (Cholangiocarcinoma) 73 Table 10: Products under Development by Universities/Institutes, Bile Duct Cancer (Cholangiocarcinoma) 80 Table 11: Number of Products by Stage and Target, Pancreatic Cancer 82 Table 12: Number of Products by Stage and Mechanism of Action, Pancreatic Cancer 94 Table 13: Number of Products by Stage and Route of Administration, Pancreatic Cancer 110 Table 14: Number of Products by Stage and Molecule Type, Pancreatic Cancer 112 Table 15: Number of Products by Stage and Target, Bile Duct Cancer (Cholangiocarcinoma) 114 Table 16: Number of Products by Stage and Mechanism of Action, Bile Duct Cancer (Cholangiocarcinoma) 118 Table 17: Number of Products by Stage and Route of Administration, Bile Duct Cancer (Cholangiocarcinoma) 122 Table 18: Number of Products by Stage and Molecule Type, Bile Duct Cancer (Cholangiocarcinoma) 124 Table 19: Pancreatic Cancer - Pipeline by 3-V Biosciences Inc 125 Table 20: Pancreatic Cancer - Pipeline by 4P-Pharma SAS 125 Table 21: Pancreatic Cancer - Pipeline by 4SC AG 126 Table 22: Pancreatic Cancer - Pipeline by AB Science SA 126 Table 23: Pancreatic Cancer - Pipeline by AbbVie Inc 127 Table 24: Pancreatic Cancer - Pipeline by AbGenomics International Inc 128 Table 25: Pancreatic Cancer - Pipeline by Ability Pharmaceuticals SL 128 Table 26: Pancreatic Cancer - Pipeline by Aclaris Therapeutics Inc 128 Table 27: Pancreatic Cancer - Pipeline by Actuate Therapeutics Inc 129 Table 28: Pancreatic Cancer - Pipeline by Adamed Sp z oo 129 Table 29: Pancreatic Cancer - Pipeline by Aduro BioTech Inc 130 Table 30: Pancreatic Cancer - Pipeline by Advantagene Inc 130 Table 31: Pancreatic Cancer - Pipeline by AGV Discovery SAS 131 Table 32: Pancreatic Cancer - Pipeline by AIMM Therapeutics BV 131 Table 33: Pancreatic Cancer - Pipeline by Alissa Pharma 132 Table 34: Pancreatic Cancer - Pipeline by Alligator Bioscience AB 132 Table 35: Pancreatic Cancer - Pipeline by Allinky Biopharma 132 Table 36: Pancreatic Cancer - Pipeline by Altor BioScience Corp 133 Table 37: Pancreatic Cancer - Pipeline by Ambrx Inc 133 Table 38: Pancreatic Cancer - Pipeline by amcure GmbH 134 Table 39: Pancreatic Cancer - Pipeline by Amgen Inc 134 Table 40: Pancreatic Cancer - Pipeline by Amplia Therapeutics Pty Ltd 135 Table 41: Pancreatic Cancer - Pipeline by Anavex Life Sciences Corp 135 Table 42: Pancreatic Cancer - Pipeline by Andarix Pharmaceuticals Inc 136 Table 43: Pancreatic Cancer - Pipeline by ANP Technologies Inc 136 Table 44: Pancreatic Cancer - Pipeline by AntiCancer Inc 136 Table 45: Pancreatic Cancer - Pipeline by APEIRON Biologics AG 137 Table 46: Pancreatic Cancer - Pipeline by Apexigen Inc 137 Table 47: Pancreatic Cancer - Pipeline by Aphios Corp 138 Table 48: Pancreatic Cancer - Pipeline by Aposense Ltd 138 Table 49: Pancreatic Cancer - Pipeline by ARMO Biosciences Inc 139 Table 50: Pancreatic Cancer - Pipeline by ArQule Inc 1391.2 List of Figures Figure 1: Number of Products under Development for Pancreatic Cancer 15 Figure 2: Number of Products under Development by Companies, Pancreatic Cancer 16 Figure 3: Number of Products under Development by Universities/Institutes, Pancreatic Cancer 29 Figure 4: Number of Products under Development for Bile Duct Cancer (Cholangiocarcinoma) 67 Figure 5: Number of Products under Development by Companies, Bile Duct Cancer (Cholangiocarcinoma) 68 Figure 6: Number of Products under Development by Universities/Institutes, Bile Duct Cancer (Cholangiocarcinoma) 72 Figure 7: Number of Products by Top 10 Targets, Pancreatic Cancer 81 Figure 8: Number of Products by Stage and Top 10 Targets, Pancreatic Cancer 81 Figure 9: Number of Products by Top 10 Mechanism of Actions, Pancreatic Cancer 93 Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions, Pancreatic Cancer 93 Figure 11: Number of Products by Top 10 Routes of Administration, Pancreatic Cancer 109 Figure 12: Number of Products by Stage and Top 10 Routes of Administration, Pancreatic Cancer 109 Figure 13: Number of Products by Top 10 Molecule Types, Pancreatic Cancer 111 Figure 14: Number of Products by Stage and Top 10 Molecule Types, Pancreatic Cancer 111 Figure 15: Number of Products by Top 10 Targets, Bile Duct Cancer (Cholangiocarcinoma) 113 Figure 16: Number of Products by Stage and Top 10 Targets, Bile Duct Cancer (Cholangiocarcinoma) 113 Figure 17: Number of Products by Top 10 Mechanism of Actions, Bile Duct Cancer (Cholangiocarcinoma) 117 Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions, Bile Duct Cancer (Cholangiocarcinoma) 117 Figure 19: Number of Products by Routes of Administration, Bile Duct Cancer (Cholangiocarcinoma) 121 Figure 20: Number of Products by Stage and Routes of Administration, Bile Duct Cancer (Cholangiocarcinoma) 121 Figure 21: Number of Products by Top 10 Molecule Types, Bile Duct Cancer (Cholangiocarcinoma) 123 Figure 22: Number of Products by Stage and Top 10 Molecule Types, Bile Duct Cancer (Cholangiocarcinoma) 123

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